Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine and CEN-092

TREK and TRESK K2P channels are widely expressed in the nervous system, particularly in sensory neurons, where they regulate neuronal excitability. In this study, using whole-cell patch-clamp electrophysiology, we characterise the inhibitory effect of the anticonvulsant lamotrigine and two derivativ...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Rep
Main Authors: Walsh, Yvonne, Leach, Michael, Veale, Emma L., Mathie, Alistair
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8144350/
https://ncbi.nlm.nih.gov/pubmed/34041373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2021.101021
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