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The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels

Pulmonary arterial hypertension (PAH) is an aggressive vascular remodeling disease that carries a high morbidity and mortality rate. Treprostinil (Remodulin) is a stable prostacyclin analogue with potent vasodilatory and anti-proliferative activity, approved by the FDA and WHO as a treatment for PAH...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Cunningham, Kevin P., Clapp, Lucie H., Mathie, Alistair, Veale, Emma L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276018/
https://ncbi.nlm.nih.gov/pubmed/34267666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.705421
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