The Reduction Potential of the Active Site Disulfides of Human Protein Disulfide Isomerase Limits Oxidation of the Enzyme by Ero1α

Disulfide formation in newly synthesized proteins entering the mammalian endoplasmic reticulum is catalyzed by protein disulfide isomerase (PDI), which is itself thought to be directly oxidized by Ero1α. The activity of Ero1α is tightly regulated by the formation of noncatalytic disulfides, which ne...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Chambers, Joseph E., Tavender, Timothy J., Oka, Ojore B. V., Warwood, Stacey, Knight, David, Bulleid, Neil J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2010
Θέματα:
Protein Synthesis and Degradation
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937950/
https://ncbi.nlm.nih.gov/pubmed/20657012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156596
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