Identification of Novel Mutations Responsible for Resistance to MK-2048, a Second-Generation HIV-1 Integrase Inhibitor

MK-2048 represents a prototype second-generation integrase strand transfer inhibitor (INSTI) developed with the goal of retaining activity against viruses containing mutations associated with resistance to first-generation INSTIs, raltegravir (RAL) and elvitegravir (EVG). Here, we report the identif...

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Main Authors: Bar-Magen, Tamara, Sloan, Richard D., Donahue, Daniel A., Kuhl, Björn D., Zabeida, Alexandra, Xu, Hongtao, Oliveira, Maureen, Hazuda, Daria J., Wainberg, Mark A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2010
主題:
Vaccines and Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937597/
https://ncbi.nlm.nih.gov/pubmed/20610719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01164-10
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