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Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes

BACKGROUND: Transcription of HIV-1 cDNA prior to, or in the absence of, integration leads to synthesis of all classes of viral RNA transcripts. Yet only a limited range of viral proteins, including Nef, are translated in this context. Nef expression from unintegrated HIV-1 DNA has been shown to redu...

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Bibliografski detalji
Glavni autori: Sloan, Richard D, Donahue, Daniel A, Kuhl, Björn D, Bar-Magen, Tamara, Wainberg, Mark A
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881062/
https://ncbi.nlm.nih.gov/pubmed/20465832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-7-44
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