Phosphoinositide-Dependent Kinase 1 Provides Negative Feedback Inhibition to Toll-Like Receptor-Mediated NF-κB Activation in Macrophages

Phosphoinositide-dependent kinase 1 (PDK-1) represents an important signaling component in the phosphatidylinositol 3-kinase (PI3K) pathway, which plays an essential role in controlling a coordinated innate immune response. Here, we show that mice with conditional disruption of PDK-1 specifically in...

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Detalhes bibliográficos
Main Authors: Chaurasia, Bhagirath, Mauer, Jan, Koch, Linda, Goldau, Julia, Kock, Anja-Sterner, Brüning, Jens C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937543/
https://ncbi.nlm.nih.gov/pubmed/20584979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00069-10
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