Phosphoinositide 3 Kinase Mediates Toll-Like Receptor 4-Induced Activation of NF-κB in Endothelial Cells

Many of the proinflammatory effects of gram-negative bacteria are elicited by the interaction of bacterial lipopolysaccharide (LPS) with Toll-like receptor 4 (TLR4) expressed on host cells. TLR4 signaling leads to activation of NF-κB and transcription of many genes involved in the inflammatory respo...

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Detalhes bibliográficos
Main Authors: Li, Xianwu, Tupper, Joan C., Bannerman, Douglas D., Winn, Robert K., Rhodes, Christopher J., Harlan, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC166052/
https://ncbi.nlm.nih.gov/pubmed/12874320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.8.4414-4420.2003
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