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The Expression Profile of the Major Mouse SPO11 Isoforms Indicates that SPO11β Introduces Double Strand Breaks and Suggests that SPO11α Has an Additional Role in Prophase in both Spermatocytes and Oocytes

Both in mice and humans, two major SPO11 isoforms are generated by alternative splicing: SPO11α (exon 2 skipped) and SPO11β. Thus, the alternative splicing event must have emerged before the mouse and human lineages diverged and was maintained during 90 million years of evolution, arguing for an ess...

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Bibliografske podrobnosti
Main Authors: Bellani, Marina A., Boateng, Kingsley A., McLeod, Dianne, Camerini-Otero, R. Daniel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937527/
https://ncbi.nlm.nih.gov/pubmed/20647542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00002-10
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