The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme

Glioblastoma multiforme (GBM) has an abysmal prognosis. We now know that the epidermal growth factor receptor (EGFR) signaling pathway along with loss of function of the tumor suppressor genes p16Ink4a/p19ARF and PTEN play a crucial role in GBM pathogenesis: initiating the early stages of tumor deve...

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Main Authors: Zhu, Haihao, Woolfenden, Steve, Bronson, Roderick T., Jaffer, Zahara M., Barluenga, Sofia, Winssinger, Nicolas, Rubenstein, Allan E., Chen, Ruihong, Charest, Al
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937276/
https://ncbi.nlm.nih.gov/pubmed/20643786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0248
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