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A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo

Heat shock proteins (HSPs) are attractive therapeutic targets for neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), characterized by aberrant formation of protein aggregates. Although motor neurons have a high threshold for activation of HSP genes, HSP90 inhibitors are effecti...

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書誌詳細
主要な著者: Cha, Jieun R. C., St. Louis, Kyle J. H., Tradewell, Miranda L., Gentil, Benoit J., Minotti, Sandra, Jaffer, Zahara M., Chen, Ruihong, Rubenstein, Allan E., Durham, Heather D.
フォーマット: Artigo
言語:Inglês
出版事項: Springer Netherlands 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982033/
https://ncbi.nlm.nih.gov/pubmed/24092395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-013-0467-2
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