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A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo

Heat shock proteins (HSPs) are attractive therapeutic targets for neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), characterized by aberrant formation of protein aggregates. Although motor neurons have a high threshold for activation of HSP genes, HSP90 inhibitors are effecti...

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Main Authors: Cha, Jieun R. C., St. Louis, Kyle J. H., Tradewell, Miranda L., Gentil, Benoit J., Minotti, Sandra, Jaffer, Zahara M., Chen, Ruihong, Rubenstein, Allan E., Durham, Heather D.
格式: Artigo
語言:Inglês
出版: Springer Netherlands 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982033/
https://ncbi.nlm.nih.gov/pubmed/24092395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-013-0467-2
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