A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo

Heat shock proteins (HSPs) are attractive therapeutic targets for neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), characterized by aberrant formation of protein aggregates. Although motor neurons have a high threshold for activation of HSP genes, HSP90 inhibitors are effecti...

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Hlavní autoři: Cha, Jieun R. C., St. Louis, Kyle J. H., Tradewell, Miranda L., Gentil, Benoit J., Minotti, Sandra, Jaffer, Zahara M., Chen, Ruihong, Rubenstein, Allan E., Durham, Heather D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2013
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982033/
https://ncbi.nlm.nih.gov/pubmed/24092395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-013-0467-2
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