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Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights
The pochoximes, based on the radicicol pharmacophore, are potent inhibitors of heat shock protein 90 (HSP90) that retain their activity in vivo. Herein we report an extended library that broadly explores the structure–activity relationship (SAR) of the pochoximes with four points of diversity. Sever...
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| Publicado no: | Chembiochem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7556317/ https://ncbi.nlm.nih.gov/pubmed/19856365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200900494 |
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