Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo

The present study tested whether aging sensitizes hippocampal microglia to a pro-inflammatory challenge ex vivo. Hippocampal microglia from 3 and 24 mo old male F344 × BN F1 rats were exposed to LPS (0, 0.1, 1, 10 and 100 ng/ml) ex vivo. 2 h post-LPS challenge, gene expression of microglial activati...

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Bibliografiske detaljer
Main Authors: Frank, Matthew G., Barrientos, Ruth M., Watkins, Linda R., Maier, Steven F.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937085/
https://ncbi.nlm.nih.gov/pubmed/20537730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2010.05.022
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