Alphavirus Replicon Particles Expressing TRP-2 Provide Potent Therapeutic Effect on Melanoma through Activation of Humoral and Cellular Immunity

BACKGROUND: Malignant melanoma is the deadliest form of skin cancer and is refractory to conventional chemotherapy and radiotherapy. Therefore alternative approaches to treat this disease, such as immunotherapy, are needed. Melanoma vaccine design has mainly focused on targeting CD8(+) T cells. Acti...

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Bibliografski detalji
Glavni autori: Avogadri, Francesca, Merghoub, Taha, Maughan, Maureen F., Hirschhorn-Cymerman, Daniel, Morris, John, Ritter, Erika, Olmsted, Robert, Houghton, Alan N., Wolchok, Jedd D.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937034/
https://ncbi.nlm.nih.gov/pubmed/20844763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012670
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