Alphavirus Replicon Particles Expressing TRP-2 Provide Potent Therapeutic Effect on Melanoma through Activation of Humoral and Cellular Immunity

BACKGROUND: Malignant melanoma is the deadliest form of skin cancer and is refractory to conventional chemotherapy and radiotherapy. Therefore alternative approaches to treat this disease, such as immunotherapy, are needed. Melanoma vaccine design has mainly focused on targeting CD8(+) T cells. Acti...

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Main Authors: Avogadri, Francesca, Merghoub, Taha, Maughan, Maureen F., Hirschhorn-Cymerman, Daniel, Morris, John, Ritter, Erika, Olmsted, Robert, Houghton, Alan N., Wolchok, Jedd D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937034/
https://ncbi.nlm.nih.gov/pubmed/20844763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012670
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