FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase–FGFR4 complex

Tumor cells use membrane type 1 matrix metalloproteinase (MT1-MMP) for invasion and metastasis. However, the signaling mechanisms that underlie MT1-MMP regulation in cancer have remained unclear. Using a systematic gain-of-function kinome screen for MT1-MMP activity, we have here identified kinases...

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Detalhes bibliográficos
Main Authors: Sugiyama, Nami, Varjosalo, Markku, Meller, Pipsa, Lohi, Jouko, Chan, Kui Ming, Zhou, Zhongjun, Alitalo, Kari, Taipale, Jussi, Keski-Oja, Jorma, Lehti, Kaisa
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936587/
https://ncbi.nlm.nih.gov/pubmed/20798051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914459107
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