EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

Changes in EphA2 signaling can affect cancer cell–cell communication and motility through effects on actomyosin contractility. However, the underlying cell–surface interactions and molecular mechanisms of how EphA2 mediates these effects have remained unclear. We demonstrate here that EphA2 and memb...

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Bibliografiska uppgifter
Huvudupphovsmän: Sugiyama, Nami, Gucciardo, Erika, Tatti, Olga, Varjosalo, Markku, Hyytiäinen, Marko, Gstaiger, Matthias, Lehti, Kaisa
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2013
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639392/
https://ncbi.nlm.nih.gov/pubmed/23629968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201205176
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