Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes

IFIH1 (interferon induced with helicase C domain 1), also known as MDA5 (melanoma differentiation-associated protein 5), is one of a family of intracellular proteins known to recognise viral RNA and mediate the innate immune response. IFIH1 is causal in type 1 diabetes based on the protective associ...

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Detalhes bibliográficos
Main Authors: Downes, Kate, Pekalski, Marcin, Angus, Karen L., Hardy, Matthew, Nutland, Sarah, Smyth, Deborah J., Walker, Neil M., Wallace, Chris, Todd, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936573/
https://ncbi.nlm.nih.gov/pubmed/20844740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012646
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