Peroxynitrite-Induced Nitration of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Promotes Their Binding in Diabetic Angiopathy

Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) play crucial roles in diabetic angiopathy. In vivo, however, the following facts remain unknown: whether COX-2 and iNOS bind, how peroxynitrite-induced nitration of COX-2 and iNOS affects their binding if they do bind and what effec...

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Hauptverfasser: Li, Yanning, Qi, Jinsheng, Liu, Kun, Li, Bin, Wang, Hui, Jia, Jinhai
Format: Artigo
Sprache:Inglês
Veröffentlicht: ScholarOne 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935956/
https://ncbi.nlm.nih.gov/pubmed/20607198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2010.00034
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