Tongxinluo Inhibits Cyclooxygenase-2, Inducible Nitric Oxide Synthase, Hypoxia-inducible Factor-2α/Vascular Endothelial Growth Factor to Antagonize Injury in Hypoxia-stimulated Cardiac Microvascular Endothelial Cells

BACKGROUND: Endothelial dysfunction is considered as the initiating process and pathological basis of cardiovascular disease. Cyclooxygenase-2 (COX-2) and prostacyclin synthase (PGIS), inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) are key enzymes with opposing actions in inflamma...

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Bibliographic Details
Published in:Chin Med J (Engl)
Main Authors: Li, Yan-Ning, Wang, Xiu-Juan, Li, Bin, Liu, Kun, Qi, Jin-Sheng, Liu, Bing-Hui, Tian, Ye
Format: Artigo
Language:Inglês
Published: Medknow Publications & Media Pvt Ltd 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832955/
https://ncbi.nlm.nih.gov/pubmed/25881609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0366-6999.155119
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