CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content

Mutations in human CEP290 cause cilia-related disorders that range in severity from isolated blindness to perinatal lethality. Here, we describe a Chlamydomonas reinhardtii mutant in which most of the CEP290 gene is deleted. Immunoelectron microscopy indicated that CEP290 is located in the flagellar...

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Autori principali: Craige, Branch, Tsao, Che-Chia, Diener, Dennis R., Hou, Yuqing, Lechtreck, Karl-Ferdinand, Rosenbaum, Joel L., Witman, George B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2010
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935561/
https://ncbi.nlm.nih.gov/pubmed/20819941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201006105
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