Pharmacokinetic/Pharmacodynamic Investigation of Colistin against Pseudomonas aeruginosa Using an In Vitro Model

Colistin plays a key role in treatment of serious infections by Pseudomonas aeruginosa. The aims of this study were to (i) identify the pharmacokinetic/pharmacodynamic (PK/PD) index (i.e., the area under the unbound concentration-time curve to MIC ratio [ƒAUC/MIC], the unbound maximal concentration...

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Detalhes bibliográficos
Main Authors: Bergen, Phillip J., Bulitta, Jurgen B., Forrest, Alan, Tsuji, Brian T., Li, Jian, Nation, Roger L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934992/
https://ncbi.nlm.nih.gov/pubmed/20585118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00903-09
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