Isoform-specific Prolongation of Kv7 (KCNQ) Potassium Channel Opening Mediated by New Molecular Determinants for Drug-Channel Interactions

Kv7 channels, especially Kv7.2 (KCNQ2) and Kv7.3 (KCNQ3), are key determinants for membrane excitability in the brain. Some chemical modulators of KCNQ channels are in development for use as anti-epileptic drugs, such as retigabine (D-23129, N-(2-amino-4-(4-fluorobenzylamino)-phenyl)), which was rec...

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Dettagli Bibliografici
Autori principali: Gao, Zhaobing, Zhang, Tangzhi, Wu, Meng, Xiong, Qiaojie, Sun, Haiyan, Zhang, Yinan, Zu, Liansuo, Wang, Wei, Li, Min
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Membrane Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934696/
https://ncbi.nlm.nih.gov/pubmed/20584905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116392
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