Isoform-specific Prolongation of Kv7 (KCNQ) Potassium Channel Opening Mediated by New Molecular Determinants for Drug-Channel Interactions

Kv7 channels, especially Kv7.2 (KCNQ2) and Kv7.3 (KCNQ3), are key determinants for membrane excitability in the brain. Some chemical modulators of KCNQ channels are in development for use as anti-epileptic drugs, such as retigabine (D-23129, N-(2-amino-4-(4-fluorobenzylamino)-phenyl)), which was rec...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gao, Zhaobing, Zhang, Tangzhi, Wu, Meng, Xiong, Qiaojie, Sun, Haiyan, Zhang, Yinan, Zu, Liansuo, Wang, Wei, Li, Min
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Membrane Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934696/
https://ncbi.nlm.nih.gov/pubmed/20584905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116392
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