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Desensitization of Chemical Activation by Auxiliary Subunits: CONVERGENCE OF MOLECULAR DETERMINANTS CRITICAL FOR AUGMENTING KCNQ1 POTASSIUM CHANNELS

Chemical openers for KCNQ potassium channels are useful probes both for understanding channel gating and for developing therapeutics. The five KCNQ isoforms (KCNQ1 to KCNQ5, or Kv7.1 to Kv7.5) are differentially localized. Therefore, the molecular specificity of chemical openers is an important subj...

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Detalhes bibliográficos
Main Authors: Gao, Zhaobing, Xiong, Qiaojie, Sun, Haiyan, Li, Min
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504881/
https://ncbi.nlm.nih.gov/pubmed/18490447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802426200
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