Innate Immune Signaling Induces High Levels of TC-specific Deaminase Activity in Primary Monocyte-derived Cells through Expression of APOBEC3A Isoforms

In HIV-1-infected individuals, G-to-A hypermutation is found in HIV-1 DNA isolated from peripheral blood mononuclear cells (PBMCs). These mutations are thought to result from editing by one or more host enzymes in the APOBEC3 (A3) family of cytidine deaminases, which act on CC (APOBEC3G) and TC (oth...

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Bibliographic Details
Main Authors: Thielen, Beth K., McNevin, John P., McElrath, M. Juliana, Hunt, Brook Vander Stoep, Klein, Kevin C., Lingappa, Jaisri R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934643/
https://ncbi.nlm.nih.gov/pubmed/20615867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102822
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