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T Cells Contain an RNase-Insensitive Inhibitor of APOBEC3G Deaminase Activity
The deoxycytidine deaminase APOBEC3G (A3G) is expressed in human T cells and inhibits HIV-1 replication. When transfected into A3G-deficient epithelial cell lines, A3G induces catastrophic hypermutation by deaminating the HIV-1 genome. Interestingly, studies suggest that endogenous A3G in T cells in...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2007
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1993843/ https://ncbi.nlm.nih.gov/pubmed/17892323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0030135 |
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