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Human Immunodeficiency Virus Type 1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses within Infected Cells

Interferon regulatory factor 3 (IRF-3) is essential for innate intracellular immune defenses that limit virus replication, but these defenses fail to suppress human immunodeficiency virus (HIV) infection, which can ultimately associate with opportunistic coinfections and the progression to AIDS. Her...

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Bibliografske podrobnosti
Main Authors: Doehle, Brian P., Hladik, Florian, McNevin, John P., McElrath, M. Juliana, Gale, Michael
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753137/
https://ncbi.nlm.nih.gov/pubmed/19706707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00849-09
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