Internal Cleavages of the Autoinhibitory Prodomain Are Required for Membrane Type 1 Matrix Metalloproteinase Activation, although Furin Cleavage Alone Generates Inactive Proteinase

The functional activity of invasion-promoting membrane type 1 matrix metalloproteinase (MT1-MMP) is elevated in cancer. This elevated activity promotes cancer cell migration, invasion, and metastasis. MT1-MMP is synthesized as a zymogen, the latency of which is maintained by its prodomain. Excision...

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Auteurs principaux: Golubkov, Vladislav S., Cieplak, Piotr, Chekanov, Alexei V., Ratnikov, Boris I., Aleshin, Alexander E., Golubkova, Natalya V., Postnova, Tatiana I., Radichev, Ilian A., Rozanov, Dmitri V., Zhu, Wenhong, Motamedchaboki, Khatereh, Strongin, Alex Y.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934640/
https://ncbi.nlm.nih.gov/pubmed/20605791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.135442
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