Internal Cleavages of the Autoinhibitory Prodomain Are Required for Membrane Type 1 Matrix Metalloproteinase Activation, although Furin Cleavage Alone Generates Inactive Proteinase

The functional activity of invasion-promoting membrane type 1 matrix metalloproteinase (MT1-MMP) is elevated in cancer. This elevated activity promotes cancer cell migration, invasion, and metastasis. MT1-MMP is synthesized as a zymogen, the latency of which is maintained by its prodomain. Excision...

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Hauptverfasser: Golubkov, Vladislav S., Cieplak, Piotr, Chekanov, Alexei V., Ratnikov, Boris I., Aleshin, Alexander E., Golubkova, Natalya V., Postnova, Tatiana I., Radichev, Ilian A., Rozanov, Dmitri V., Zhu, Wenhong, Motamedchaboki, Khatereh, Strongin, Alex Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934640/
https://ncbi.nlm.nih.gov/pubmed/20605791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.135442
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