Kit(low) stem cells cause resistance to Kit/Pdgfra inhibitors in murine gastrointestinal stromal tumors

BACKGROUND & AIMS: Gastrointestinal stromal tumors (GIST) are related to interstitial cells of Cajal (ICC) and often contain activating Kit or Pdgfra mutations. Inhibitors of Kit/Pdgfra signaling such as imatinib mesylate have increased progression-free survival in metastatic GIST but are not cu...

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Hlavní autoři: Bardsley, Michael R., Horváth, Viktor J., Asuzu, David T., Lorincz, Andrea, Redelman, Doug, Hayashi, Yujiro, Popko, Laura N., Young, David L., Lomberk, Gwen A., Urrutia, Raul A., Farrugia, Gianrico, Rubin, Brian P., Ordog, Tamas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933938/
https://ncbi.nlm.nih.gov/pubmed/20621681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.05.083
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