Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging

BACKGROUND: Gastrointestinal symptoms, particularly constipation, increase with aging, but their underlying mechanisms are poorly understood due to a lack of experimental models. Previously we established the progeric klotho mouse as a model of aging-associated anorexia and gastric dysmotility. We a...

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Detalhes bibliográficos
Main Authors: Asuzu, David T., Hayashi, Yujiro, Izbeki, Ferenc, Popko, Laura N., Young, David L., Bardsley, Michael R., Lorincz, Andrea, Kuro-o, Makoto, Linden, David R., Farrugia, Gianrico, Ordog, Tamas
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149585/
https://ncbi.nlm.nih.gov/pubmed/21605285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2982.2011.01730.x
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