Development of a novel tumor-targeted vascular disrupting agent activated by MT-MMPs

Vascular disrupting agents (VDA) offer a strategy to starve solid tumors of nutrients and oxygen concomitant with tumor shrinkage. Several VDAs have progressed into early clinical trials but their therapeutic value seems to be compromised by systemic toxicity. In this report, we describe the design...

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Bibliografiske detaljer
Main Authors: Atkinson, Jennifer M, Falconer, Robert A, Edwards, Dylan R, Pennington, Caroline J, Siller, Catherine S, Shnyder, Steven D, Bibby, Michael C, Patterson, Laurence H, Loadman, Paul M, Gill, Jason H
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933508/
https://ncbi.nlm.nih.gov/pubmed/20663911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1440
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