Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts

The role of de novo mutations (DNMs) in common diseases remains largely unknown. Nonetheless, the rate of de novo deleterious mutations and the strength of selection against de novo mutations are critical to understanding the genetic architecture of a disease. Discovery of high-impact DNMs requires...

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Bibliografski detalji
Glavni autori: Awadalla, Philip, Gauthier, Julie, Myers, Rachel A., Casals, Ferran, Hamdan, Fadi F., Griffing, Alexander R., Côté, Mélanie, Henrion, Edouard, Spiegelman, Dan, Tarabeux, Julien, Piton, Amélie, Yang, Yan, Boyko, Adam, Bustamante, Carlos, Xiong, Lan, Rapoport, Judith L., Addington, Anjené M., DeLisi, J. Lynn E., Krebs, Marie-Odile, Joober, Ridha, Millet, Bruno, Fombonne, Éric, Mottron, Laurent, Zilversmit, Martine, Keebler, Jon, Daoud, Hussein, Marineau, Claude, Roy-Gagnon, Marie-Hélène, Dubé, Marie-Pierre, Eyre-Walker, Adam, Drapeau, Pierre, Stone, Eric A., Lafrenière, Ronald G., Rouleau, Guy A.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2010
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933353/
https://ncbi.nlm.nih.gov/pubmed/20797689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2010.07.019
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