Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts

The role of de novo mutations (DNMs) in common diseases remains largely unknown. Nonetheless, the rate of de novo deleterious mutations and the strength of selection against de novo mutations are critical to understanding the genetic architecture of a disease. Discovery of high-impact DNMs requires...

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Главные авторы: Awadalla, Philip, Gauthier, Julie, Myers, Rachel A., Casals, Ferran, Hamdan, Fadi F., Griffing, Alexander R., Côté, Mélanie, Henrion, Edouard, Spiegelman, Dan, Tarabeux, Julien, Piton, Amélie, Yang, Yan, Boyko, Adam, Bustamante, Carlos, Xiong, Lan, Rapoport, Judith L., Addington, Anjené M., DeLisi, J. Lynn E., Krebs, Marie-Odile, Joober, Ridha, Millet, Bruno, Fombonne, Éric, Mottron, Laurent, Zilversmit, Martine, Keebler, Jon, Daoud, Hussein, Marineau, Claude, Roy-Gagnon, Marie-Hélène, Dubé, Marie-Pierre, Eyre-Walker, Adam, Drapeau, Pierre, Stone, Eric A., Lafrenière, Ronald G., Rouleau, Guy A.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933353/
https://ncbi.nlm.nih.gov/pubmed/20797689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2010.07.019
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