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Pronounced Virus-dependent Activation Drives Exhaustion but Sustains Interferon-γ Transcript Levels
During many chronic infections the responding CD8 T cells become exhausted as they progressively lose their ability to elaborate key effector functions. Unlike prototypic memory CD8 cells, which rapidly synthesize IFN-γ following activation, severely exhausted T cells fail to produce this effector m...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2933304/ https://ncbi.nlm.nih.gov/pubmed/20720198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000841 |
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