Lovastatin Inhibits VEGFR and AKT Activation: Synergistic Cytotoxicity in Combination with VEGFR Inhibitors

BACKGROUND: In a recent study, we demonstrated the ability of lovastatin, a potent inhibitor of mevalonate synthesis, to inhibit the function of the epidermal growth factor receptor (EGFR). Lovastatin attenuated ligand-induced receptor activation and downstream signaling through the PI3K/AKT pathway...

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Bibliographische Detailangaben
Hauptverfasser: Zhao, Tong T., Trinh, Diane, Addison, Christina L., Dimitroulakos, Jim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933231/
https://ncbi.nlm.nih.gov/pubmed/20838437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012563
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