Combination of eribulin plus AKT inhibitor evokes synergistic cytotoxicity in soft tissue sarcoma cells

An activated AKT pathway underlies the pathogenesis of soft tissue sarcoma (STS), with over-expressed phosphorylated AKT (p-AKT) correlating with a poor prognosis in a subset of STS cases. Recently, eribulin, a microtubule dynamics inhibitor, has demonstrated efficacy and is approved in patients wit...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hayasaka, Naotaka, Takada, Kohichi, Nakamura, Hajime, Arihara, Yohei, Kawano, Yutaka, Osuga, Takahiro, Murase, Kazuyuki, Kikuchi, Shohei, Iyama, Satoshi, Emori, Makoto, Sugita, Shintaro, Hasegawa, Tadashi, Takasawa, Akira, Miyanishi, Koji, Kobune, Masayoshi, Kato, Junji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453888/
https://ncbi.nlm.nih.gov/pubmed/30962488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42300-z
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