The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma

Deregulated iron metabolism underlies the pathogenesis of many human cancers. Recently, low expression of ferroportin, which is the only identified non-heme iron exporter, has been associated with significantly reduced overall survival in multiple myeloma (MM); however, the altered iron metabolism i...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Kamihara, Yusuke, Takada, Kohichi, Sato, Tsutomu, Kawano, Yutaka, Murase, Kazuyuki, Arihara, Yohei, Kikuchi, Shohei, Hayasaka, Naotaka, Usami, Makoto, Iyama, Satoshi, Miyanishi, Koji, Sato, Yasushi, Kobune, Masayoshi, Kato, Junji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325446/
https://ncbi.nlm.nih.gov/pubmed/27602957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11830
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