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Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents

As a part of our continuing study of colchicinoids as therapeutically useful antitumor drugs, thiocolchicine derivatives, including their phosphate and other water soluble salts, were synthesized and evaluated for inhibition of tubulin polymerization and for in vitro cytotoxicity. Three compounds, 7...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Kozaka, Takashi, Nakagawa-Goto, Kyoko, Shi, Qian, Lai, Chin-Yu, Hamel, Ernest, Bastow, Kenneth F., Brossi, Arnold, Lee, Kuo-Hsiung
التنسيق: Artigo
اللغة:Inglês
منشور في: 2010
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933066/
https://ncbi.nlm.nih.gov/pubmed/20542428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.05.081
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