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Arsenic Trioxide and the PI3K/AKT Pathway in Chronic Lymphocytic Leukemia
Simultaneous targeting of the PI3K/AKT pathway increases arsenic trioxide (ATO)-dependent cytotoxicity of chronic lymphocytic leukemia (CLL) cells, while it has no significant effects on normal lymphocytes. Combinations of ATO with small molecules that target the PI3’ kinase and/or AKT may provide a...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2932783/ https://ncbi.nlm.nih.gov/pubmed/20622048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1496 |
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