Recombinant human parainfluenza virus type 2 with mutations in V that permit cellular interferon signaling are not attenuated in non-human primates

The HPIV2 V protein inhibits type I interferon (IFN) induction and signaling. To manipulate the V protein, whose coding sequence overlaps that of the polymerase-associated phosphoprotein (P), without altering the P protein, we generated an HPIV2 virus in which P and V are expressed from separate gen...

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Detalhes bibliográficos
Main Authors: Schaap-Nutt, Anne, D’Angelo, Christopher, Amaro-Carambot, Emerito, Nolan, Sheila M., Davis, Stephanie, Wise, Shenelle-Marie, Higgins, Caraline, Bradley, Konrad, Kim, Olivia, Mayor, Reina, Skiadopoulos, Mario H., Collins, Peter L., Murphy, Brian R., Schmidt, Alexander C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932766/
https://ncbi.nlm.nih.gov/pubmed/20667570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.07.011
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