Identification of Human Parainfluenza Virus Type 2 (HPIV-2) V Protein Amino Acid Residues That Reduce Binding of V to MDA5 and Attenuate HPIV-2 Replication in Nonhuman Primates

Human parainfluenza virus type 2 (HPIV-2), an important pediatric respiratory pathogen, encodes a V protein that inhibits type I interferon (IFN) induction and signaling. Using reverse genetics, we attempted the recovery of a panel of V mutant viruses that individually contained one of six cysteine-...

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Main Authors: Schaap-Nutt, Anne, Higgins, Caraline, Amaro-Carambot, Emerito, Nolan, Sheila M., D'Angelo, Christopher, Murphy, Brian R., Collins, Peter L., Schmidt, Alexander C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126142/
https://ncbi.nlm.nih.gov/pubmed/21289116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02542-10
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