Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire

The size and sensitivity of the T-cell repertoire governs the effectiveness of immune responses against invading pathogens. Both are modulated by T-cell receptor (TCR) activity through molecular mechanisms, which remain unclear. Here, we provide genetic evidence that the SH2/SH3 domain containing pr...

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Autori principali: Roy, Edwige, Togbe, Dieudonnée, Holdorf, Amy D., Trubetskoy, Dmitry, Nabti, Sabrina, Küblbeck, Günter, Klevenz, Alexandra, Kopp-Schneider, Annette, Leithäuser, Frank, Möller, Peter, Bladt, Friedhelm, Hämmerling, Günter, Arnold, Bernd, Pawson, Tony, Tafuri, Anna
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932578/
https://ncbi.nlm.nih.gov/pubmed/20709959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009743107
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