Structural Basis for Different Specificities of Acyltransferases Associated with the Human Cytosolic and Mitochondrial Fatty Acid Synthases

Animals employ two systems for the de novo biosynthesis of fatty acids: a megasynthase complex in the cytosol (type I) that produces mainly palmitate, and an ensemble of freestanding enzymes in the mitochondria (type II) that produces mainly octanoyl moieties. The acyltransferases responsible for in...

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Hauptverfasser: Bunkoczi, Gabor, Misquitta, Stephanie, Wu, Xiaoqiu, Lee, Wen Hwa, Rojkova, Alexandra, Kochan, Grazyna, Kavanagh, Kathryn L, Oppermann, Udo, Smith, Stuart
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931828/
https://ncbi.nlm.nih.gov/pubmed/19549604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.04.011
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