Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry

S-acylation is a major posttranslational modification, catalyzed by the zinc finger DHHC domain containing (zDHHC) enzyme family. S-acylated proteins can be modified by different fatty acids; however, very little is known about how zDHHC enzymes contribute to acyl chain heterogeneity. Here, we used...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Greaves, Jennifer, Munro, Kevin R., Davidson, Stuart C., Riviere, Matthieu, Wojno, Justyna, Smith, Terry K., Tomkinson, Nicholas C. O., Chamberlain, Luke H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338407/
https://ncbi.nlm.nih.gov/pubmed/28167757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612254114
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