Structural Basis for Different Specificities of Acyltransferases Associated with the Human Cytosolic and Mitochondrial Fatty Acid Synthases

Animals employ two systems for the de novo biosynthesis of fatty acids: a megasynthase complex in the cytosol (type I) that produces mainly palmitate, and an ensemble of freestanding enzymes in the mitochondria (type II) that produces mainly octanoyl moieties. The acyltransferases responsible for in...

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Autores principales: Bunkoczi, Gabor, Misquitta, Stephanie, Wu, Xiaoqiu, Lee, Wen Hwa, Rojkova, Alexandra, Kochan, Grazyna, Kavanagh, Kathryn L, Oppermann, Udo, Smith, Stuart
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931828/
https://ncbi.nlm.nih.gov/pubmed/19549604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.04.011
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