Telomerase Inhibition Targets Clonogenic Multiple Myeloma Cells through Telomere Length-Dependent and Independent Mechanisms

BACKGROUND: Plasma cells constitute the majority of tumor cells in multiple myeloma (MM) but lack the potential for sustained clonogenic growth. In contrast, clonotypic B cells can engraft and recapitulate disease in immunodeficient mice suggesting they serve as the MM cancer stem cell (CSC). These...

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Detalhes bibliográficos
Main Authors: Brennan, Sarah K., Wang, Qiuju, Tressler, Robert, Harley, Calvin, Go, Ning, Bassett, Ekaterina, Huff, Carol Ann, Jones, Richard J., Matsui, William
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931698/
https://ncbi.nlm.nih.gov/pubmed/20824134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012487
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