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Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
Once immortalized, human cells are susceptible to transformation by introduction of an oncogene such as ras. Several lines of evidence now suggest that the maintenance of telomere length is a major determinant of replicative lifespan in human cells and thus of the immortalized state. The majority of...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC130507/ https://ncbi.nlm.nih.gov/pubmed/12193655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182407599 |
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