Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

Once immortalized, human cells are susceptible to transformation by introduction of an oncogene such as ras. Several lines of evidence now suggest that the maintenance of telomere length is a major determinant of replicative lifespan in human cells and thus of the immortalized state. The majority of...

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Bibliografski detalji
Glavni autori: Stewart, Sheila A., Hahn, William C., O'Connor, Benjamin F., Banner, Elisa N., Lundberg, Ante S., Modha, Poonam, Mizuno, Hana, Brooks, Mary W., Fleming, Mark, Zimonjic, Drazen B., Popescu, Nicholas C., Weinberg, Robert A.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC130507/
https://ncbi.nlm.nih.gov/pubmed/12193655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182407599
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