Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

Once immortalized, human cells are susceptible to transformation by introduction of an oncogene such as ras. Several lines of evidence now suggest that the maintenance of telomere length is a major determinant of replicative lifespan in human cells and thus of the immortalized state. The majority of...

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Bibliografische gegevens
Hoofdauteurs: Stewart, Sheila A., Hahn, William C., O'Connor, Benjamin F., Banner, Elisa N., Lundberg, Ante S., Modha, Poonam, Mizuno, Hana, Brooks, Mary W., Fleming, Mark, Zimonjic, Drazen B., Popescu, Nicholas C., Weinberg, Robert A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 2002
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC130507/
https://ncbi.nlm.nih.gov/pubmed/12193655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182407599
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