Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

Once immortalized, human cells are susceptible to transformation by introduction of an oncogene such as ras. Several lines of evidence now suggest that the maintenance of telomere length is a major determinant of replicative lifespan in human cells and thus of the immortalized state. The majority of...

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Autors principals: Stewart, Sheila A., Hahn, William C., O'Connor, Benjamin F., Banner, Elisa N., Lundberg, Ante S., Modha, Poonam, Mizuno, Hana, Brooks, Mary W., Fleming, Mark, Zimonjic, Drazen B., Popescu, Nicholas C., Weinberg, Robert A.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC130507/
https://ncbi.nlm.nih.gov/pubmed/12193655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182407599
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